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| From the PET scan, we got extra information about whether the plaques were dangerous and whether they could lead to problems for patients, he added. The combined imaging techniques focused not only on the structure of plaque but also on the underlying molecular biology of the disease in the hope of guiding and monitoring future therapies, said Rudd. PET is a highly specialized, noninvasive imaging technique that uses short-lived radioactive substances to produce three-dimensional color images of those substances functioning within the body. Unlike CT, which provides anatomic images, PET scanning provides information about the body's chemistry, metabolic activity and function not available through other procedures. Rudd explained that the Mount Sinai study was performed using an animal model of atherosclerosis that behaves like the disease in humans. Additional research needs to be done with heart disease and stroke patients to see if our approach gives more information than the traditionally used technique of invasive X-ray coronary angiography, he said. Rudd, who also holds a position at the Division of Cardiovascular Medicine in Cambridge, United Kingdom, said that part of the work at Mount Sinai was funded by the British Heart Foundation, a charity that supports research and education about heart disease. This work features the enhanced imaging of atherosclerotic plaques - using a novel combination of technologies, said Josef Machac, SNM's Scientific Program Committee cardiovascular vice chair.
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FDG-PET has been demonstrated to be taken up in macrophage-rich plaques, indicating an inflammatory component of atherosclerosis, added the director of nuclear medicine at the Mount Sinai School of Medicine in New York City. Fayad, Imaging Science Laboratory, Mount Sinai School of Medicine, New York, N. Machac, Division of Nuclear Medicine, Mount Sinai Hospital, New York, N. Molecular Imaging of Atherosclerosis Using FDG PET/CT With a Novel, Macrophage-Specific CT Contrast Agent, SNM's 54th Annual Meeting, June 2-6, 2007. About SNM - Advancing Molecular Imaging and Therapy SNM held its 54th Annual Meeting June 2-6 at the Washington Convention Center in Washington, D. Session topics for the 2007 meeting include brain amyloid imaging, hybrid imaging, molecular imaging in clinical drug development and evaluation, functional brain imaging in epilepsy and dementia, imaging instrumentation, infection imaging, lymphoma and thyroid cancer, cardiac molecular imaging, general nuclear medicine, critical elements of care in radiopharmacy and more. SNM is an international scientific and professional organization of more than 16,000 members dedicated to promoting the science, technology and practical applications of molecular and nuclear imaging to diagnose, manage and treat diseases in women, men and children.
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