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| The trial included a one-week test phase to ensure that subjects could tolerate three different dose levels of the medication, followed by a four-week (crossover) phase in which children were given one of three doses of methylphenidate or placebo to assess effectiveness. Parents, teachers and investigators, who rated the child's behavior, were blind to the child's drug dose. Children showing a positive response to any dose during the crossover phase were treated for an additional eight-week period to ensure the gains were stable. The study evaluated 72 children between the ages of five and 14. Of the 58 participants who completed the crossover phase, 35 responded best to an active dose of methylphenidate and the drug was consistently more effective than placebo on measures of inattention, hyperactivity and impulsivity rated by parents and teachers. The National Institute of Mental Health funded the study.
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Other Yale authors on the study were Andres Martin, M. Kathleen Koenig, Deirdre Carroll, Christopher Young, M. Authors from the RUPP Autism Network were from Indiana University, Johns Hopkins University, The Ohio State University, UCLA, the General Clinical Research Centers, National Center for Research Resources and the Korczak Foundation. Citation: Archives of General Psychiatry, 62: 1266-74 (November 2005) Yale News Releases are available via the World Wide Web at Review finds more work needed in planning services and personalising care Local councils and primary care trusts (PCTs) need to plan better for the needs of people with a learning disability and complex needs to ensure care is accessible, personalised and allows service users to lead as full and independent lives as possible. The Commission for Social Care Inspection (CSCI), the Healthcare Commission and the Mental Health Act Commission (MHAC), today published a joint report reviewing how councils and PCTs commission services on behalf of people with a learning disability. The watchdogs conducted the review following a series of reports over the past decade that point to poor care for people with a learning disability, particularly those with complex needs.
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